7 This necessitates a prolonged process of planning and execution, which can cause an insufficient supply of vaccines if some batches do not meet quality standards. 1, 2, 5, 6 First, this production method requires the availability of a large number of eggs in a short period of time, and poses an increased risk of contamination that requires the use of anti-infective agents. 4 In addition, the conventional methods of producing inactivated influenza vaccines in the allantoic cavity of embryonated chicken eggs, have important limitations. 3 However, influenza vaccines must be produced “ad hoc” each season to correspond to the constantly changing antigenic characteristics of circulating influenza viruses. 1, 2 Vaccination is the most effective public health intervention for reducing the impact of seasonal influenza.
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